Immunotherapy Mechanisms
Articles on the biological mechanisms of immunotherapy, including checkpoint inhibition, B-cell activation, antibody production, and systemic immune responses in cancer.
Unseen Targets: How Long-Read Sequencing Unlocked Glioblastoma's Hidden Secrets
Researchers developed the most comprehensive map to date of isoform diversity in glioblastoma using single-cell long-read RNA sequencing. The study uncovered thousands of previously unannotated, tumor-specific genetic isoforms that remained undetected by conventional short-read sequencing. A subset of these novel isoforms can bind MHC Class I molecules, presenting new targets for personalized cancer vaccines and immunotherapies in adult neuro-oncology.
The Neck, Not the Brain: How B Cells Secretly Run Anti-CTLA-4 Immunotherapy for Glioma
A KAIST study shows that anti-CTLA-4 checkpoint inhibitors work against glioblastoma only when B cells in the deep cervical lymph nodes produce IgG antibodies — not through local T-cell attack as oncology textbooks have assumed for decades.