APOE ε4 and Neuroinflammation
APOE ε4 and Neuroinflammation
Articles on the role of the APOE ε4 allele in driving neuroinflammation, microglial dysfunction, and systemic immune responses in late-onset Alzheimer’s disease and related neurodegenerative conditions.
apoe 4 and neuroinflammationJul 3, 20264 min
The Silent Fire: How APOEε4 Ignites Brain Inflammation Decades Before Alzheimer's Symptoms
The APOEε4 allele reprograms microglia into a chronic inflammatory state via the cPLA2 enzyme switch, creating a self-sustaining neuroinflammatory cascade that precedes amyloid plaques by years — but new small-molecule inhibitors and AI-driven drug discovery offer a window for pre-symptomatic intervention.