Neurodegenerative Biomarkers & Genetics
Articles on genetic risk factors, biomarkers, and molecular mechanisms underlying neurodegenerative diseases including Alzheimer's, Parkinson's, and related conditions.
UCSF Launches the Alzheimer's Tau Platform: How Neurotechnology and Brain-Computer Interfaces Are Reshaping Alzheimer's Prevention
UCSF's Alzheimer's Tau Platform trial tests combination therapies targeting amyloid and tau simultaneously in asymptomatic patients — and it's part of a broader neurotechnology revolution.
Sleep Complaints, Tau Tangles, and the Women at Highest Risk
A 2026 UC San Diego study finds that in older women with elevated polygenic Alzheimer's risk, worse sleep quality correlates with reduced visual memory and increased tau tangles — but only in that high-risk group, suggesting sleep may be a modifiable early-warning signal.
Your Sleep, Your Genes: How AQP4 Variants Turn Poor Rest Into Brain Shrinkage
A new study from Edith Cowan University reveals that specific AQP4 gene variants — which regulate the brain's overnight glymphatic waste-clearance system — interact with sleep duration and latency to accelerate grey matter thinning and cognitive decline in preclinical Alzheimer's, suggesting a modifiable pathway for personalized prevention.